A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants비강 오미크론 백신 부스터는 새로운 SARS-CoV-2 변이체에 대한 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absence adjuvants administration antibody Antibody Response boost booster Bronchoalveolar lavage caused clinical trial composed COVID-19 COVID-19 pandemic current deaths delta variant described disease severity domain dose effective Elevation elicit evidenced FIVE fused human infection human infections humans IgA Immunity immunogen intranasal leads mice MOST mucosal nasal nasal protein vaccine booster Neutralizing activity neutralizing antibody Neutralizing antibody response omicron Omicron variant omicron variant. Protein Receptor binding domain reduce respiratory SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 spike SARS-CoV-2 transmission SARS-CoV-2 variant severity significantly single dose suggested the antibody response the disease vaccination Vaccine virus infection wild-type [DOI] 10.1080/22221751.2022.2053365 PMC 바로가기 [Article Type] Article
Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines포괄적인 백신 패널에 의해 유도된 오미크론 스파이크 기능 및 중화 활성Article Published on 2022-08-192022-09-11 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 Antibody titers binding booster breadth coronavirus dominant elicited evade evaluated homologous or heterologous Infection leads Neutralizing activity Neutralizing antibody response Neutralizing antibody titer neutralizing antibody titers omicron plasma polyclonal Prevalence reduced replaced respiratory SARS-CoV-2 sequence Seven severe acute respiratory syndrome Coronavirus severe disease spike mutation Vaccine variant virus Wuhan-Hu-1 [DOI] 10.1126/science.abq0203 PMC 바로가기 [Article Type] Article
Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution viral evolution. virus virus entry virus spread [DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article
Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress진단 후 6개월째 COVID-19 생존자의 심리적 결과: 우울증, 불안 및 스트레스에서 키누레닌 경로 대사물의 역할Article Published on 2022-08-012022-09-11 Journal: Journal of neural transmission (Vienna, Austria : [Category] MERS, 바이오마커, [키워드] 3-hydroxykynurenine Activation Admission alteration Anxiety anxiety symptom Biomarker Biomarkers both groups center change coronavirus disease Coronavirus disease 2019 correlation COVID-19 DASS-21 Depression depressive Depressive symptoms exhibited Follow-up healthy control healthy controls Hospitalization illnesses immune response immunologic response in both groups increase in Inflammation initial initial assessment Kynurenic acid Kynurenine Kynurenine pathway leads life mechanism Mental metabolism metabolite outcome pandemic participant pathophysiology pathway plasma Plasma levels post-COVID-19 patient Post-COVID-19 patients predicted predictor Psychiatric psychiatric disorder Psychiatric disorders questionnaire reduction in Stress Stress Scale survivor Symptom target therapy to define TRP Tryptophan Tryptophan. Viral viral infection viral infections virus was used with COVID-19 [DOI] 10.1007/s00702-022-02525-1 PMC 바로가기 [Article Type] Article
SARS-CoV-2-Specific T Cell Immunity in HIV-Associated Kaposi Sarcoma Patients in Zambia잠비아의 HIV 관련 카포시 육종 환자의 SARS-CoV-2-특이적 T 세포 면역Article Published on 2022-07-282022-09-11 Journal: Journal of Immunology Research [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect affecting baseline level baseline levels Cancer caused CD4 CD4 count Cell-mediated immunity Chemotherapy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death Depletion detectable Factor Follow-up Frame had no higher risk HIV infection immune response Immunity Immunosuppression impair increase individual Infection investigated Kaposi sarcoma leads malignancies malignancy membrane protein nucleoprotein Open reading frame Patient peptide peptide pool Population Protein reported respiratory response risk Sarcoma SARS-CoV-2 SARS-COV-2 infection seropositive Severe acute respiratory syndrome severe disease significant effect statistically significant symptomatic SARS-CoV-2 infection T cell T cell response T cell responses T cells Viral viral infection viral infections virus with HIV [DOI] 10.1155/2022/2114285 PMC 바로가기 [Article Type] Article
Structure-based drug repurposing: Traditional and advanced AI/ML-aided methods구조 기반 약물 용도 : 전통 및 고급 AI/ML 보조 방법Review Published on 2022-07-012022-08-31 Journal: Drug discovery today [Category] 신약개발, [키워드] Algorithm applied approach approved drugs artificial intelligence computational method Computational methods coronavirus COVID-19 drug Drug discovery Drug repurposing force Force field Generative modeling health emergency highlight identify in silico in vitro initial inverse Inverse design leads machine machine learning molecules pandemic pharmacokinetic Quantum mechanics Quantum mechanics. resource Stage Traditional [DOI] 10.1016/j.drudis.2022.03.006 PMC 바로가기 [Article Type] Review
The SARS-CoV-2 helicase as a target for antiviral therapy: Identification of potential small molecule inhibitors by in silico modelling항바이러스 치료의 표적으로서의 SARS-CoV-2 헬리카제: in silico 모델링을 통한 잠재적인 소분자 억제제 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Acetylcysteine active site acute respiratory syndrome addition anti-inflammatory property Antiviral antiviral activity antiviral therapeutics antivirals binding free energy clavulanic acid Compound coronavirus coronavirus disease COVID-19 DHX9 DNA DNA2 expected Fatty acid fatty acids free energies Helicase Hepatitis hepatitis C highlighting identification identify in silico include inhibitor inhibitory activity initial lead leads Ligand MERS-CoV molecular dynamics Molecular dynamics simulation molecular dynamics simulations non-structural protein nsp13 nsp13. nucleoside performed reported Research respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 nsp13 selected sequence Severe acute respiratory syndrome small molecule inhibitor specific inhibitor specific inhibitors strain structural homology structural proteins Structure structures synthetic the SARS-CoV-2 utilised Vaccine variant was performed were used [DOI] 10.1016/j.jmgm.2022.108193 PMC 바로가기 [Article Type] Article
Comparison of neutralizing antibody response in first and second waves of SARS-CoV-2 pandemic in India인도 SARS-CoV-2 대유행의 1차 및 2차 파동에서 중화항체 반응 비교Article Published on 2022-05-312022-09-11 Journal: Journal of Travel Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Delta delta variant elicited First wave immune response increase in India leads Neutralizing neutralizing antibody Neutralizing antibody response resurgence robust SARS CoV SARS CoV-2 SARS-CoV-2 pandemic second wave variant variants variants of concerns. [DOI] 10.1093/jtm/taab196 PMC 바로가기 [Article Type] Article
Sex differences in global metabolomic profiles of COVID-19 patientsCOVID-19 환자의 글로벌 대사 프로필의 성별 차이Article Published on 2022-05-142022-09-11 Journal: Cell Death & Disease [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료제, [키워드] amino acids analysis aromatic amino acids Asymptomatic disease bile acid Biomarker caused change changes in clinical parameter controls coronavirus coronavirus disease correlation correlations COVID-19 COVID-19 patient COVID-19 patients death demonstrated disease examined female patient groups identification involved knowledge leads lipid metabolism male metabolic pathway metabolic pathways metabolism metabolomic Mortality pathway Patient pentose performed profile profiles researcher robust SARS-CoV-2 serum samples severe COVID-19 severe COVID-19 patient severe COVID-19 patients severe symptom severe symptoms Sex Sex difference sexual dimorphism statistical analysis susceptible Symptom target therapeutic target therapeutic targets treat Tryptophan tyrosine uninfected [DOI] 10.1038/s41419-022-04861-2 PMC 바로가기 [Article Type] Article
Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19SARS-CoV-2에 감염된 Caco-2 장 세포에서 CDH1/E-Cadherin 유전자 발현 및 가용성 형태의 E-Cadherin 방출 제어: COVID-19의 장 형태에 대한 생리병리학적 결과Article Published on 2022-05-042022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] 24 hour 24 hours 48 hour 48 hours ACE2 ACE2 mRNA Affect AT1 Caco-2 Caco-2 cell Caco-2 cells cadherin CDH1 Cell cell line cells Co-receptor connexin consequence contributing to Control COVID-19 Culture culture supernatant diarrhoea diarrhoea) digestive tract Disruption dissemination down-regulated dysregulation E-cadherin ENCODE epithelial exposure to expresse expression form Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract HCoV HCoV-OC43 HLA class I human ACE2 illnesses in viral induce infected with SARS-CoV-2 Infection intestinal intestinal barrier. intestinal cells intestinal tissue intranasal involved JAMA junctions leads membrane mRNA mRNA expression OC43 occludin pandemic Patient Physiopathological Post-infection Protein receptor receptor ACE2 Release remained reported respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection significant increase significantly lower Symptom the disease these symptoms TMPRSS2 Transcription transgenic mice Trigger Viral viral entry virus [DOI] 10.3389/fcimb.2022.798767 PMC 바로가기 [Article Type] Article